Southeast Asia’s geopolitical dynamics in the post-pandemic era are undergoing significant transformation, driving changes in international relations and security strategies. The region’s economic, political and social sectors are starting to recover after the negative impacts caused by COVID-19, but new challenges are emerging in the form of regional conflicts and great power competition. One key aspect of this dynamic is China’s increasing influence in Southeast Asia. The Belt and Road Initiative (BRI) investment shows Beijing’s ambition to expand its infrastructure network and economic influence. Countries such as Laos and Myanmar have felt the positive impact of this initiative, although some countries such as Vietnam and the Philippines have expressed concerns about over-dependence on China. Meanwhile, the United States is trying to strengthen its presence through the Indo-Pacific Strategy, by increasing defense and economic cooperation with allied countries. This political maneuvering is evident in joint military exercises, as well as new trade agreements, which are bringing Southeast Asia back into the global spotlight. On the other hand, ASEAN plays an important role in creating stability in the region. Through the 2025 vision, ASEAN seeks to strengthen economic integration and political cooperation. However, tensions in the South China Sea continue to be a controversial issue that drives debate within the organization. ASEAN’s consensus approach is sometimes hampered by divergent national interests, creating challenges to respond quickly to changing situations. Furthermore, non-traditional security issues, such as terrorism and climate change, also shape the geopolitical architecture in Southeast Asia. Countries in the region are starting to realize the need for close regional collaboration to overcome this challenge, for example through the exchange of intelligence information and more comprehensive disaster mitigation policies. Apart from that, post-pandemic social shifts also have a significant impact in the geopolitical context. People who are more aware of the importance of public health and the environment encourage the government to transform to be more responsive and inclusive, thereby influencing domestic political dynamics. Amidst all this, the active involvement of youth and civil society organizations in public discussions creates space for transparency and freedom of speech, which was previously hampered. This phenomenon has triggered changes in policies that are more democratic in several countries. Overall, the Southeast Asia region is entering a complex and dynamic phase in the geopolitical context. With major powers competing to influence this region, countries in Southeast Asia must strategically position themselves to take advantage of opportunities while facing existing challenges. Adaptation and innovation in policy are the keys so that every country can adapt to ever-changing situations and maintain resilience in this post-pandemic era.